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The SYMBA Study

SYMBA is promoting gut health (symbiosis) with prebiotic fibre taken during pregnancy for prevention of allergic disease.

Allergic diseases including eczema, asthma, hay fever and food allergies now affect 30-40% of the Australian population.

One in every four children will suffer from eczema and asthma, while one in every ten children will have at least one food allergy.

We now know that a baby's immune system begins to develop even before birth, and that the mother's diet and her environment in pregnancy can have an important influence. Research shows that the mother's gut health may have important effects on the immune development of her baby. 

'Prebiotics' is a general term for non-digestible dietary fibre that promote health and well-being by inducing the growth and/or activity of beneficial gut bacteria. Prebiotics occur naturally in grains, legumes, vegetables, fruit and breast milk. The supplement and dose to be used in this study has the demonstrated prebiotic properties of a high fibre diet, including favourable effects on gut bacteria and immune health. 

Recruitment for this study is now closed.

In total, 652 women and their babies were recruited.

Pregnant women have received either a prebiotic supplement or a placebo supplement. They are being asked to take the supplement from 18-20 weeks gestation until their baby is 6 months of age. The study is then examining whether supplementing the mother's diet during pregnancy and breastfeeding with the prebiotic fibre will reduce the development of allergies in her child.

For further information: 

Published Papers

NUTRIENTS PUBLICATION

Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months’ Post-Partum on Child Allergic Disease Outcomes

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CLINICAL NUTRITION PUBLICATION

Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant

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PEDIATRIC ALLERGY AND IMMUNOLOGY PUBLICATION

Effect of maternal prebiotic supplementation on human milk immunological composition: Insights from the SYMBA study

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JOURNAL OF ALLERGY & CLINICAL IMMUNOLGY PUBLICATION

Effects of pregnancy and lactation prebiotics supplementation on infant allergic disease: A randomized controlled trial

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JOURNAL OF ALLERGY & CLINICAL IMMUNOLOGY PUBLICATION

Infant diet recommendations reduce IgE-mediated egg, peanut, and cows milk allergies.

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NUTRITION JOURNAL PUBLICATION

Body mass index, prebiotic supplementation during pregnancy and gestational diabetes mellitus risk: An effect modification analysis from a randomised controlled trial

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