Allergy, Inflammation & Immunity

ORIGINS has several sub-projects exploring allergy development within the cohort, with a focus on respiratory conditions such as asthma and nutritional strategies for allergy prevention.

We all take breathing for granted, yet the community and healthcare costs of respiratory illnesses in children, such as wheeze and asthma, are enormous.

In addition, food allergies in children continue to present a significant health concern, with 10% of babies expected to develop an adverse reaction to certain foods by the age of one.

ORIGINS has several sub-projects exploring allergy development within the cohort and the possible translation of these findings.

Areas covered by this research domain include:

Allergies and atopy
Infections and infectious diseases (including COVID-19)
Immunisations and immune function

Active

RHINO

RHINO researchers from The Kids' Wal-yan Respiratory Research Centre, will analyse ORIGINS data and turn it into meaningful respiratory and allergy outcome data that can be used by researchers around the world.

AERIAL

Investigating the possible contributors to childhood lung disease by studying the epithelial cells from the nose at birth.

PrEggNut

PrEggNut is aiming to determine whether mothers regularly eating more eggs and peanuts during pregnancy and breastfeeding will reduce food allergies in their babies.

Caesarean Section, Maternal Stress & Phototherapy

This sub-project is exploring associations with eczema, food allergy and wheeze in children of the ORIGINS cohort.

Maternal Inflamma Types

This study is exploring what role maternal inflammation during pregnancy plays in 'programming' adverse child health outcomes.

Completed

BENEFIT Trial

Breastfeeding and Eating Nuts and Eggs for Infant Tolerance

The Cashew Study

Does eating cashew nut spreads in the first year of life reduce the chances a baby will develop a cashew nut food allergy?

COCOON

Assessing the virus transmission, immunity development and wellbeing of families during COVID-19

The Mast Cell Study

Comparing how mast cells are “programmed” in allergic and non-allergic children at one year of age.